Dimethyl Sulfoxide
Apexbio Technology LLC Trifluoperazine 2HCl 440-17-5 10mM (in 1mL DMSO)
Trifluoperazine 2HCl is a dopamine D2 receptor antagonist extensively utilized in biomedical research for investigating dopaminergic signaling pathways It functions by selectively inhibiting the D2 subtype dopamine receptor exhibiting an IC50 value of approximately 1 1 nM Due to its receptor-blocking mechanism trifluoperazine is frequently employed to study dopamine-mediated neurotransmission receptor pharmacodynamics and neurological processes underlying disorders involving altered dopaminergic activity such as schizophrenia Additionally trifluoperazine serves as a tool compound for elucidating cellular responses linked to dopaminergic receptor modulation in in vitro receptor-binding assays and neuronal cell cultures
Apexbio Technology LLC GDC-0994 1453848-26-4 10mM (in 1mL DMSO)
GDC-0994 (CAS 1453848-26-4) is a selective small-molecule inhibitor targeting extracellular signal-regulated kinases 1 and 2 (ERK1/2) components of the MAP kinase signaling cascade downstream of RAS/RAF/MEK ERK1/2 mediates cell proliferation and differentiation frequently activated due to oncogenic mutations in RAS and BRAF GDC-0994 shows inhibition of ERK1 and ERK2 with IC50 values of 1 1 and 0 3 nM respectively In preclinical models bearing KRAS or BRAF mutant tumor xenografts oral administration of GDC-0994 suppresses ERK phosphorylation and downstream signaling demonstrating significant anti-tumor activity GDC-0994 is a potent tool for studying ERK signaling in cancer research
Apexbio Technology LLC Etomidate 10mM (in 1mL DMSO)
A1958 is a small molecule utilized in biomedical research that acts primarily as an inhibitor targeting specific signaling pathways or protein interactions relevant to cellular processes The compound s mechanism typically involves selective modulation or inhibition of targeted biomolecules influencing downstream biological pathways A1958 serves as a research tool for studying cellular mechanisms underlying disease states aiding in cell-based assays to elucidate molecular function and clarify therapeutic targets in biomedical studies
Apexbio Technology LLC YM155 781661-94-7 10mM (in 1mL DMSO)
YM155 (Sepantronium Bromide CAS 781661-94-7) is a small-molecule inhibitor targeting survivin the smallest protein member of the inhibitor of apoptosis (IAP) gene family YM155 potently suppresses survivin expression while demonstrating minimal influence on other IAP family members or BCL-2-associated proteins Preclinical research shows YM155 inhibits proliferation and induces apoptosis across various human cancer cell lines including non-small cell lung cancer (NSCLC) melanoma bladder cancer aggressive non-Hodgkin lymphoma triple-negative breast cancer (TNBC) and Wilms tumor models In animal xenograft studies YM155 administration results in tumor regression reduces spontaneous metastasis and notably prolongs survival
Apexbio Technology LLC SB 431542 301836-41-9 10mM (in 1mL DMSO)
SB 431542 (CAS number 301836-41-9) is a selective ATP-competitive inhibitor targeting activin receptor-like kinase 5 (ALK5) a type I receptor within the transforming growth factor- (TGF- ) signaling pathway It inhibits ALK5 activity with an IC50 value of 94 nM thereby preventing phosphorylation of Smad2 proteins and their subsequent nuclear accumulation Additionally SB 431542 inhibits closely related receptors ALK4 and ALK7 while showing minimal or no significant activity against ALK1 ALK2 ALK3 and ALK6 at relevant concentrations Commonly utilized in cellular assays to investigate TGF- signaling this compound is valuable for studying associated cellular processes and diseases
Medchemexpress LLC ML-792 | CAS No. : 1644342-14-2 | 10 mM * 1 mL in DMSO
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively).
Apexbio Technology LLC Amantadine HCl 665-66-7 10mM (in 1mL DMSO)
Amantadine Hydrochloride a dopamine receptor agonist is primarily employed as a research tool in neuroscience and antiviral studies It exerts its antiparkinsonian effects by promoting dopamine release and inhibiting dopamine reuptake consequently enhancing dopaminergic neurotransmission As an antiviral agent amantadine hydrochloride inhibits influenza A virus replication through blockade of the viral matrix protein M2 ion channel In cell-based assays amantadine hydrochloride demonstrates inhibitory activity against influenza A viruses with reported IC50 values typically ranging between 0 3 to 1 5 M depending on assay conditions and viral strains Researchers commonly utilize this compound to investigate neurological pathways associated with Parkinson s disease viral infection mechanisms and drug resistance phenomena
Apexbio Technology LLC HOAt 39968-33-7 10mM (in 1mL DMSO)
HOAt (1-Hydroxy-7-azabenzotriazole) is a peptide coupling reagent frequently employed in peptide synthesis for the activation of carboxylic groups Structurally HOAt serves as an activating additive that forms reactive intermediates facilitating amide bond formation while mitigating side reactions such as racemization As reported in experimental peptide coupling studies combining HOAt with diisopropylcarbodiimide (DIC) promotes coupling reactions with improved retention of stereochemical integrity relative to traditional coupling systems utilizing other benzotriazole derivatives HOAt is thus commonly used both in segment coupling and stepwise solid-phase peptide assembly methodologies aimed at synthesizing peptides requiring minimal epimerization
Apexbio Technology LLC GSK-923295 1088965-37-0 10mM (in 1mL DMSO)
GSK-923295 (CAS 1088965-37-0) is a highly potent inhibitor targeting the centromere-associated protein E (CENP-E) a kinesin motor protein essential for proper chromosome alignment and progression from metaphase to anaphase during cell division By blocking microtubule-stimulated ATPase activity of CENP-E GSK-923295 stabilizes an ATP-bound intermediate resulting in significantly reduced enzymatic function (IC50 3 2 nM) In cellular models GSK-923295 induces mitotic arrest with morphological changes similar to CENP-E knockdown In mouse xenograft models using Colo205 colon carcinoma cells administration of GSK-923295 leads to tumor growth inhibition and increased apoptosis supporting its utility in cancer research
Apexbio Technology LLC Rifaximin (Xifaxan) 80621-81-4 10mM (in 1mL DMSO)
Rifaximin (Xifaxan) a rifamycin derivative is a nonabsorbable antibiotic targeting bacterial RNA synthesis by binding to the -subunit of bacterial DNA-dependent RNA polymerase In vitro rifaximin also functions as an intestinal-specific agonist for human pregnane X receptor (PXR) modulating intestinal immune responses Rifaximin (EC50 20 M) activates human PXR reducing inflammatory cytokine expression induced by LPS in human colonic biopsies In animal models rifaximin alters intestinal expression of PXR-responsive genes relevant to drug metabolism and lipid homeostasis Clinically rifaximin has been utilized in research on hepatic encephalopathy and irritable bowel syndrome (IBS)
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitabl
Dimethyl sulfoxide (DMSO) is a polar organic solvent. DMSO activated by various electrophiles (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. Due to its higher stability it has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction.
Medchemexpress LLC HY-Y0320 200mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 200mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Azd0780 10Mm 1Ml Dmso Reconst | HY-148673-10MM DMSO RECON
Azd0780 10Mm 1Ml Dmso Reconst
Apexbio Technology LLC GM 6001 142880-36-2 10mM (in 1mL DMSO)
GM 6001 (Ilomastat Galardin CAS 142880-36-2) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) including MMP-1 -2 -3 -8 and -9 with reported Ki values of 0 4 nM 0 5 nM 27 nM 0 1 nM and 0 2 nM respectively MMPs participate in extracellular matrix remodeling and mediate signaling events induced by GPCR agonists through EGFR transactivation GM 6001 suppresses EGFR phosphorylation ERK activation and subsequent DNA synthesis induced by stimuli such as bombesin and lysophosphatidic acid (LPA) Additionally this compound has potential applications in cartilage research facilitating meniscal repair under inflammatory conditions by dampening IL-1-mediated MMP activity