Dimethyl Sulfoxide
Apexbio Technology LLC LY2157299(Synonyms: Galunisertib, LY-2157299, LY2157299 monohydrate, LY2157299 hydrate, LY2157299 free base), 10mM (in 1mL DMSO), CAS: 700874-72-2.
LY2157299 (CAS 700874-72-2) is a small-molecule antagonist that selectively targets the transforming growth factor-beta type I receptor (T RI) By blocking signaling through T RI it prevents phosphorylation of downstream effectors Smad2 and Smad3 thereby interfering with the TGF- signaling pathway Preclinical studies indicate LY2157299 inhibits 1-integrin activation reduces tumor cell invasion lowers connective tissue growth factor (CTGF) production and suppresses angiogenesis Currently in phase II clinical trials LY2157299 is being investigated primarily for therapeutic potential against hepatocellular carcinoma and glioblastoma
Apexbio Technology LLC Kaempferol(Synonyms: Kempferol, Kaempherol, Kaempferide, Robigenin, Rhamnolutein, Populnetin), 10mM (in 1mL DMSO), CAS: 520-18-3.
Kaempferol (CAS 520-18-3) is a naturally derived flavonoid isolated from sources including Gingko biloba and red wine It functions biologically by activating the mitochondrial calcium uniporter (EC50 7 M) Additionally kaempferol promotes apoptosis through the caspase-9 pathway by suppressing polo-like kinase 1 (PLK1) expression thereby inhibiting cancer cell proliferation in diverse cell lines It also demonstrates antioxidant properties and reduces osteoclast-mediated bone resorption in vitro These characteristics make kaempferol valuable for researching mitochondrial physiology cancer biology and bone metabolism
Apexbio Technology LLC Z-Ligustilide 4431-01-0 10mM (in 1mL DMSO)
Ligustilide a bioactive compound purified from Angelica essential oil exhibits anti-inflammatory and anti-apoptotic properties and is commonly investigated for circulatory improvement and inflammation-related studies In vitro data demonstrate ligustilide s capability to interfere with apoptotic signaling pathways in neuronal cell models by modulating factors such as mitochondrial cytochrome C release Bcl-2/Bax ratios and Caspase-3 expression Additionally in animal models of ovariectomy-induced osteoporosis ligustilide administration reduces inflammatory markers including NF- B activation and production of cytokines (TNF- IL-1 ) and enzymes (COX-2 iNOS) suggesting potential therapeutic relevance in inflammation-associated conditions
Apexbio Technology LLC Nanaomycin A 52934-83-5 10mM (in 1mL DMSO)
Nanaomycin A is a selective inhibitor targeting DNA methyltransferase 3B (DNMT3B) with an IC50 of approximately 500 nM It acts by specifically inhibiting DNMT3B-mediated DNA methylation without notably affecting DNMT1 activity In cell-based studies employing cancer cell lines such as HCT116 A549 and HL60 treatment with Nanaomycin A reduced global DNA methylation levels and reactivated transcription of tumor suppressor genes previously silenced via promoter hypermethylation Its use in epigenetics-related research includes quantitative assessment of DNMT3B function investigation of DNA methylation regulation mechanisms and evaluation of gene reactivation consequent to DNMT3B inhibition
Apexbio Technology LLC YM201636 371942-69-7 10mM (in 1mL DMSO)
YM201636 is a cell-permeable selective inhibitor of the mammalian class III phosphatidylinositol phosphate kinase PIKfyve It functions by targeting and inhibiting PIKfyve enzymatic activity at an IC50 of approximately 33 nM thus reducing the biosynthesis of phosphatidylinositol (3 5)-bisphosphate (PtdIns(3 5)P2) Treatment of various mammalian cell lines (including NIH3T3 MDCK MCF10A COS7 and MEFs) with YM201636 induces the formation of enlarged intracellular vacuoles pointing toward changes in endosomal transport and membrane trafficking Furthermore YM201636 has shown utility in studying insulin-mediated signaling by inhibiting insulin-dependent class I PI3K activation lowering Akt phosphorylation and preventing surface translocation of GLUT4 in adipocytes Researchers frequently utilize this compound to analyze intracellular vesicular transport pathways and phosphoinositide-dependent signaling events
Medchemexpress LLC Pemigatinib | 1513857-77-6 | 487.5 g/mol | 1ML
Pemigatinib | 1513857-77-6 | 487.5 g/mol | 1ML
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 50mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, BioPerformance Certified, suitable for hybridoma, Ready-to-use sterile filtered product conveniently packaged in septum screw-capped amber bottles. Meets USP and EP testing requirements.
Apexbio Technology LLC Flucytosine 2022-85-7 10mM (in 1mL DMSO)
Flucytosine also known as 5-Fluorocytosine (5-FC) is a fluorinated pyrimidine analogue with antifungal properties It exerts its biological activity by penetrating fungal cells and undergoing intracellular conversion into 5-fluorouracil (5-FU) via cytosine deaminase Subsequently 5-FU metabolites inhibit nucleic acid synthesis interfering with fungal RNA and DNA synthesis pathways thus blocking cellular proliferation In laboratory experiments Flucytosine is commonly utilized for antifungal susceptibility assays fungal growth inhibition studies as well as research into antifungal resistance mechanisms The typical reported in vitro antifungal activity displays IC50 values ranging from approximately 0 12 to 8 g/mL depending on fungal species and experimental conditions
Apexbio Technology LLC Cyclo (-RGDfK) 161552-03-0 10mM (in 1mL DMSO)
Cyclo(-RGDfK) is a cyclic pentapeptide that functions as an inhibitor targeting the integrin v 3 Integrins are transmembrane receptors mediating cell adhesion by recognizing specific peptide sequences notably the Arg-Gly-Asp (RGD) motif Integrin v 3 is involved in cell adhesion processes such as angiogenesis tissue remodeling and tumor development and is abundantly expressed on activated endothelial cells and various tumor cells Cyclo(-RGDfK) specifically binds integrin v 3 disrupting integrin-mediated cell attachment Consequently it is frequently utilized in bioengineering applications to modify biomaterial surfaces for enhanced cellular adherence and integration Additionally cyclo(-RGDfK) serves as a targeting ligand in imaging probes aimed at localizing integrin-positive tissues in cancer research
Apexbio Technology LLC THZ2 1604810-84-5 10mM (in 1mL DMSO)
THZ2 (CAS 1604810-84-5) is a selective inhibitor of cyclin-dependent kinase 7 (CDK7) demonstrating an IC50 of 13 9 nM CDK7 a serine/threonine kinase bound and activated by cyclins regulates cell cycle progression and transcriptional control through phosphorylation of RNA polymerase II (RNAPII) In triple-negative breast cancer (TNBC) cell models THZ2 reduces cellular proliferation induces apoptotic cell death without affecting cell-cycle distribution and inhibits colony formation at low-nanomolar concentrations (IC50 10 nM) In xenograft mouse models THZ2 suppresses tumor growth without noticeable toxicity Thus THZ2 is useful in research investigating CDK7-mediated oncogenic mechanisms in cancer
Apexbio Technology LLC CX-4945 (Silmitasertib) 1009820-21-6 10mM (in 1mL DMSO)
CX-4945 (Silmitasertib CAS 1009820-21-6) is an orally bioavailable inhibitor targeting casein kinase 2 (CK2) via ATP-competitive binding with an IC50 of approximately 1 nM It suppresses CK2-mediated signaling pathways notably by reducing phosphorylation of Akt at Ser129 independently of PTEN activation thus impacting PI3K/Akt pathway regulation In vitro studies report that CX-4945 treatment leads to increased total expression and decreased phosphorylation of cell cycle regulators p21 and p27 causing cell cycle arrest (G2/M in BT-474 breast carcinoma G1 in BxPC-3 pancreatic carcinoma) In vivo it displays antitumor activity in BxPC-3 mouse xenograft models highlighting its utility for oncology research