Dimethyl Sulfoxide
Apexbio Technology LLC Dioscin 19057-60-4 10mM (in 1mL DMSO)
Dioscin (CAS 19057-60-4) is a steroidal saponin isolated primarily from Dioscorea nipponica Makino Structurally it belongs to glycosidic steroid derivatives known for modulating various biological pathways Dioscin exerts bioactivity predominantly through regulation of cellular signaling cascades such as apoptosis induction anti-inflammatory responses and oxidative stress reduction Studies suggest that dioscin interacts with signaling pathways including PI3K/Akt ERK/MAPK and NF- B Due to these activities dioscin is commonly investigated for its potential anti-inflammatory anticancer and antioxidant effects making it relevant for biomedical research focused on chronic inflammation and cancer therapeutics
Apexbio Technology LLC Polydatin 27208-80-6 10mM (in 1mL DMSO)
Polydatin (CAS 27208-80-6) is a naturally occurring stilbenoid isolated primarily from the roots of Polygonum cuspidatum Structurally it represents the glucoside derivative of resveratrol exerting antioxidant and anti-inflammatory effects through modulation of oxidative stress-related pathways Research indicates that polydatin influences signaling cascades such as NF- B MAPK and Nrf2 contributing to its protective roles in cellular injury models including cardiovascular dysfunction neurodegeneration and inflammatory conditions Polydatin is soluble in methanol ethanol and acetone and stability is maintained by storage under sealed cool dry conditions
Apexbio Technology LLC BQU57 1637739-82-2 10mM (in 1mL DMSO)
BQU57 (CAS 1637739-82-2) is a small-molecule inhibitor derived from RBC8 selectively targeting the GDP-bound form of the Ral GTPases BQU57 binds preferentially to RalB-GDP exhibiting measured dissociation constants (Kd) of approximately 7 7 M (ITC) and 4 7 M (SPR) In vitro assays using cell lines such as H2122 and H358 have shown suppression of Ral-dependent anchorage-independent colony formation at IC50 values of 2 0 M and 1 3 M respectively In mouse xenograft tumor models administration of BQU57 resulted in reduced activation of RalA and RalB without affecting Ras or RhoA signaling highlighting its utility as a tool compound for investigating Ral-driven tumor biology
Apexbio Technology LLC Piceatannol 10083-24-6 10mM (in 1mL DMSO)
Piceatannol (CAS 10083-24-6) is a naturally occurring small molecule exhibiting anti-inflammatory immunomodulatory and antiproliferative activities It functions primarily by inhibiting protein tyrosine kinases including p56lck and syk kinases and suppressing tumor necrosis factor (TNF)-induced nuclear factor-kappa B (NF- B) activation and downstream gene expression Biologically piceatannol arises as a metabolite of resveratrol through oxidation by cytochrome P450 1B1 This compound is employed in biomedical research to explore kinase signaling pathways inflammatory response regulation and potential therapeutic interventions
Apexbio Technology LLC Ondansetron hydrochloride dihydrate 103639-04-9 10mM (in 1mL DMSO)
Ondansetron hydrochloride dihydrate (CAS 103639-04-9) is a small molecule antagonist targeting the serotonin (5-HT3) receptor a ligand-gated ion channel prominent in the central and peripheral nervous systems Through blockade of 5-HT3 receptor signaling ondansetron inhibits serotonin-induced emetic responses Due to this mechanism it is widely utilized in biomedical research investigating serotonin-related signaling pathways and nausea mechanisms particularly in contexts involving chemotherapy-induced emesis
Apexbio Technology LLC Enrofloxacin 93106-60-6 10mM (in 1mL DMSO)
Enrofloxacin a fluoroquinolone antibiotic exerts antibacterial activity by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes essential for DNA replication and transcription This mechanism disrupts the DNA synthesis of pathogenic bacteria resulting in bacteriostatic outcomes In vitro experiments indicate that Enrofloxacin displays antimicrobial activity against Mycoplasma species such as Mycoplasma bovis with a minimum inhibitory concentration (MIC90) around 0 312 g/mL In biomedical research this compound is primarily utilized to establish microbial infection models and to study bacterial resistance mechanisms pharmaceutical efficacy and antibacterial pharmacodynamics
Apexbio Technology LLC MK-8745 885325-71-3 10mM (in 1mL DMSO)
MK-8745 (CAS 885325-71-3) is a small-molecule inhibitor targeting Aurora A kinase a serine/threonine kinase regulating chromosomal segregation during mitosis Aberrant Aurora A activity correlates with cancer progression In preclinical studies MK-8745 suppresses Aurora A kinase eliciting p53-dependent apoptosis and G2/M cell cycle arrest MK-8745 demonstrates antitumor activity in vitro across various cancer cell lines including p53-deficient and checkpoint-defective HCT116 variants and inhibits tumor growth in xenografted tumor models signifying its potential utility in cancer research targeting Aurora kinase pathways
Apexbio Technology LLC Torsemide 56211-40-6 10mM (in 1mL DMSO)
Torsemide a pyridine-sulfonyl urea derivative acts pharmacologically as a loop diuretic by selectively inhibiting the Na -K -2Cl cotransporter (NKCC2) located in the thick ascending limb of Henle s loop Through this mechanism torsemide reduces sodium chloride and water reabsorption resulting in increased urinary excretion of electrolytes and water Chemically characterized by a sulfonylurea moiety linked to pyridine functionality torsemide is utilized in pharmacological research to investigate kidney function fluid-electrolyte balance and associated physiological responses Additionally researchers employ torsemide as a tool compound to study ion transport regulation pathways and the pathophysiology underlying edema and hypertension at a molecular and cellular level
Apexbio Technology LLC (-)-Blebbistatin 856925-71-8 10mM (in 1mL DMSO)
(-)-Blebbistatin is a cell-permeable small molecule inhibitor targeting non-muscle myosin II (NM II) an actin-dependent motor protein involved in cell adhesion migration and differentiation It selectively binds the myosin-ADP-phosphate complex slowing phosphate release and thereby suppressing Mg-ATPase and contractile activities mediated by actomyosin interactions It exhibits inhibitory potency in various model systems (IC50 0 5 5 0 M) with minimal effects on myosin isoforms I V X and reduced activity toward smooth muscle myosin II (IC50 80 M) Its reversible modulation of NM II renders it useful in research on cytoskeletal dynamics cell mechanics and related pathophysiological conditions
Apexbio Technology LLC P005091 882257-11-6 10mM (in 1mL DMSO)
P005091 (CAS 882257-11-6) is an inhibitor that selectively targets the ubiquitin-specific protease 7 (USP7) also known as herpes-associated ubiquitin-specific protease (HAUSP) By blocking USP7-mediated deubiquitination P005091 promotes degradation of HDM2 resulting in altered regulation of downstream targets including increased cellular levels of tumor suppressor proteins p53 and p21 Through USP7 inhibition P005091 can downregulate claspin and suppress phosphorylation of DNA checkpoint kinase Chk1 enhancing genotoxic drug sensitivity and inducing apoptosis in cancer cell lines irrespective of p53 mutational status This makes P005091 relevant as a research probe for studying USP7-dependent signaling pathways and cancer cell biology
Apexbio Technology LLC SU11274 658084-23-2 10mM (in 1mL DMSO)
SU11274 (CAS 658084-23-2) is a selective inhibitor targeting Met kinase exhibiting an IC50 of approximately 10 nM The compound specifically suppresses the autophosphorylation of Met at residues Tyr1234/1235 disrupting receptor activity with minimal effects on other receptor tyrosine kinases such as EGFR and PDGFR or serine/threonine kinases including CDK2 In NIH3T3 cells expressing drug-sensitive or resistant MET mutants and in H1993 human lung cancer cells treatment with SU11274 induces a dose-dependent inhibition of Met phosphorylation and impairs receptor ubiquitination leading to receptor accumulation SU11274 serves as a useful tool for investigating Met signaling pathways in oncology research
Apexbio Technology LLC Meptazinol HCl 59263-76-2 10mM (in 1mL DMSO)
Meptazinol HCl also chemically known as WY-22811 hydrochloride is a centrally acting analgesic agent characterized as a partial agonist at the 1 opioid receptor Structurally it belongs to the synthetic opioid family and interacts selectively with opioid receptors in the central nervous system to modulate pain transmission Its partial agonist properties allow for analgesic activity with generally reduced risk of respiratory depression compared to full opioid agonists making it a useful compound in pharmacological studies examining opioid receptor activation modulation and analgesic effects In biomedical research settings Meptazinol HCl is commonly employed to investigate pain management mechanisms opioid receptor signaling pathways receptor selectivity profiles and analgesia-related side effect mitigation
Apexbio Technology LLC Bendamustine HCl 3543-75-7 10mM (in 1mL DMSO)
Bendamustine HCl (CAS 3543-75-7) is an alkylating agent that induces cytotoxicity primarily through DNA damage Mechanistically it disrupts the mitotic checkpoint by downregulating key regulators such as polo-like kinase 1 Aurora kinase A and cyclin B1 leading to mitotic failure and subsequent apoptosis In myeloma models bendamustine activates apoptosis signaling that involves ATM-mediated G2 cell cycle arrest cleavage of caspase-3 and mitochondrial apoptotic pathways It demonstrates dose-dependent antiproliferative activity in dexamethasone-sensitive (MM1 S IC50 119 8 M) and resistant (MM1 R IC50 138 M) multiple myeloma cell lines Bendamustine represents a useful research tool for studying DNA damage response and apoptosis in hematological malignancy contexts
Apexbio Technology LLC Taxifolin 480-18-2 10mM (in 1mL DMSO)
Taxifolin (CAS number 480-18-2) a bioactive flavonoid isolated primarily from coniferous species of the Pinaceae family exhibits notable antioxidant anti-inflammatory and chemopreventive properties It functions primarily through free radical scavenging and modulation of oxidative stress pathways reducing cellular damage associated with reactive oxygen species (ROS) Taxifolin further influences various signaling cascades involved in inflammation and apoptosis regulation Due to these pharmacological attributes it is widely utilized in biomedical research exploring oxidative stress-related diseases inflammatory conditions and potential cancer therapeutic avenues For optimal stability maintain storage conditions sealed dry and cool